Fig. 6. SM compounds decrease endothelial tube formation. a) Representative images of HUVEC cells from three independent experiments where cells were treated with N-terminal HSP90 inhibitor 17-AAG, or one of the C-terminal inhibitors, SM122, SM252, or SM258 and plated on EHS matrix. Images taken after 18 hours at 10× magnification. b) Tubule formation was quantified using ImageJ with the add-on Angiogenesis Analyzer (NIH) (n = 3). Mean ± SEM shown with individual values.